AlphaFold predicted structure
CASP10 · Q92851
Mean pLDDT
68.8/ 100
Low
521 residues
Confidence breakdown
- Very high(≥ 90)41%
- Confident(70–90)19%
- Low(50–70)4%
- Very low(< 50)35%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
CASP10
Chr 2q33.1caspase 10
- Aliases:
- MCH4, FLICE-2
- MANE:
- ENST00000286186.11
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCytopenia - NOT Fanconi anaemia
BOTH monoallelic and biallelic, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
autoimmune lymphoproliferative syndrome type 2A
0.63gastric cancer
0.56autoimmune lymphoproliferative syndrome
0.55lymphoma
0.46non-Hodgkin lymphoma
0.46B-cell chronic lymphocytic leukemia
0.32rheumatoid arthritis
0.24lymphoma, non-Hodgkin, familial
0.18alcohol drinking
0.16stroke disorder
0.16
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Caspase-10
Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP8 and CASP9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC
Diseases associated with CASP10
Curated MONDO disease pages that list CASP10 among their top associated genes.