CAT

Chr 11p13

catalase

MANE:: ENST00000241052.5

OMIM: 115500 ↗NCBI: 847 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CAT · P04040

v62025-08-01

Predicted Aligned Error matrix for CAT — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

95.8/ 100

Very high

527 residues

Confidence breakdown

Very high(≥ 90)95%
Confident(70–90)0%
Low(50–70)1%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Likely inborn error of metabolism
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Peroxisomal disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Undiagnosed metabolic disorders
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Childhood onset dystonia, chorea or related movement disorder

Disease associations (Open Targets)

acatalasia
0.69
type 2 diabetes mellitus
0.36
COVID-19
0.28
major depressive disorder
0.25
neurodegenerative disease
0.22
narcolepsy
0.22
Intellectual disability
0.12
neoplasm
0.12
hepatocellular carcinoma
0.11
hydrops fetalis
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Catalase

Catalyzes the degradation of hydrogen peroxide (H(2)O(2)) generated by peroxisomal oxidases to water and oxygen, thereby protecting cells from the toxic effects of hydrogen peroxide (PubMed:7882369). Promotes growth of cells including T-cells, B-cells, myeloid leukemia cells, melanoma cells, mastocytoma cells and normal and transformed fibroblast cells (PubMed:7882369)