CCL2

Chr 17q12

C-C motif chemokine ligand 2

Aliases:: MCP1, MCP-1, MCAF, SMC-CF, GDCF-2
MANE:: ENST00000225831.4

OMIM: 158105 ↗NCBI: 6347 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CCL2 · P13500

v62025-08-01

Predicted Aligned Error matrix for CCL2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.9/ 100

Confident

99 residues

Confidence breakdown

Very high(≥ 90)61%
Confident(70–90)22%
Low(50–70)16%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial Meniere Disease
Familial Neural Tube Defects
Pancreatitis

Disease associations (Open Targets)

HIV-1 infection
0.38
Crohn disease
0.37
alcohol drinking
0.36
inflammatory bowel disease
0.32
Abnormality of the skeletal system
0.31
ulcerative colitis
0.31
urolithiasis
0.28
cartilage disease
0.28
colitis
0.27
psoriasis
0.26

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

C-C motif chemokine 2

Acts as a ligand for C-C chemokine receptor CCR2 (PubMed:10529171, PubMed:10587439, PubMed:9837883). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:10587439, PubMed:9837883). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (PubMed:8195247, PubMed:8627182, PubMed:9792674). May be involved in the recruitment of monocytes into the arterial wall during the disease process of atherosclerosis (PubMed:8107690)