CCNK

Chr 14q32.2

cyclin K

Aliases:: CPR4
MANE:: ENST00000389879.9

OMIM: 603544 ↗NCBI: 8812 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CCNK · O75909

v62025-08-01

Predicted Aligned Error matrix for CCNK — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

65.1/ 100

Low

580 residues

Confidence breakdown

Very high(≥ 90)40%
Confident(70–90)2%
Low(50–70)11%
Very low(< 50)47%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

HIV infectious disease
0.56
intellectual developmental disorder with hypertelorism and distinctive facies
0.54
neurodegenerative disease
0.43
cancer
0.08
lung cancer
0.08
lung carcinoma
0.08
breast carcinoma
0.08
breast cancer
0.08
neoplasm
0.06
endometrial cancer
0.05

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclin-K

Regulatory subunit of cyclin-dependent kinases that mediates activation of target kinases. Plays a role in transcriptional regulation via its role in regulating the phosphorylation of the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A)