AlphaFold predicted structure
CCNO · P22674
Mean pLDDT
78.4/ 100
Confident
350 residues
Confidence breakdown
- Very high(≥ 90)58%
- Confident(70–90)14%
- Low(50–70)2%
- Very low(< 50)26%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CCNO
Chr 5q11.2cyclin O
- Aliases:
- UDG2, FLJ22422, UNG2
- MANE:
- ENST00000282572.5
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
BIALLELIC, autosomal or pseudoautosomalPrimary ciliary disorders
BIALLELIC, autosomal or pseudoautosomalRespiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomalIntellectual disability
BIALLELIC, autosomal or pseudoautosomalLaterality disorders and isomerism
Rare multisystem ciliopathy disorders
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
primary ciliary dyskinesia
0.78hereditary disease
0.19Hydrocephalus
0.08gastric cancer
0.08nephronophthisis
0.07Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus
0.06glioblastoma
0.06neoplasm
0.06Hydrolethalus
0.05holoprosencephaly
0.05
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cyclin-O
Specifically required for generation of multiciliated cells, possibly by promoting a cell cycle state compatible with centriole amplification and maturation. Acts downstream of MCIDAS to promote mother centriole amplification and maturation in preparation for apical docking
Diseases associated with CCNO
Curated MONDO disease pages that list CCNO among their top associated genes.