CCT3

Chr 1q22

chaperonin containing TCP1 subunit 3

Aliases:: Cctg
MANE:: ENST00000295688.8

OMIM: 600114 ↗NCBI: 7203 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CCT3 · P49368

v62025-08-01

Predicted Aligned Error matrix for CCT3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.1/ 100

Confident

545 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)28%
Low(50–70)2%
Very low(< 50)4%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Malformations of cortical development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Optic neuropathy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
White matter disorders and cerebral calcification - narrow panel
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

neurodevelopmental disorder with speech or visual impairment and brain hypomyelination
0.62
neurodegenerative disease
0.47
autoimmune disorder of central nervous system
0.25
osteoarthritis
0.22
uterine corpus leiomyoma
0.17
atrial fibrillation
0.14
hepatocellular carcinoma
0.11
neoplasm
0.11
breast cancer
0.10
breast carcinoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

T-complex protein 1 subunit gamma

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638)