CCT6A

Chr 7p11.2

chaperonin containing TCP1 subunit 6A

Aliases:: TTCP20, TCPZ, Cctz, HTR3, TCP20
MANE:: ENST00000275603.9

OMIM: 104613 ↗NCBI: 908 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CCT6A · P40227

v62025-08-01

Predicted Aligned Error matrix for CCT6A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

89.9/ 100

Confident

531 residues

Confidence breakdown

Very high(≥ 90)66%
Confident(70–90)32%
Low(50–70)1%
Very low(< 50)1%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodevelopmental disorder
0.37
neurodegenerative disease
0.34
ulcer of lower limb
0.26
leg injury
0.22
coronary artery disorder
0.20
complex neurodevelopmental disorder
0.18
diabetic neuropathy
0.13
peripheral neuropathy
0.12
neoplasm
0.11
colorectal carcinoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

T-complex protein 1 subunit zeta

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444)