CCT8

Chr 21q21.3

chaperonin containing TCP1 subunit 8

Aliases:: Cctq, PRED71
MANE:: ENST00000286788.9

OMIM: 617786 ↗NCBI: 10694 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CCT8 · P50990

v62025-08-01

Predicted Aligned Error matrix for CCT8 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.7/ 100

Confident

548 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)36%
Low(50–70)4%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Malformations of cortical development
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

colorectal carcinoma
0.09
hepatocellular carcinoma
0.09
neoplasm
0.09
cancer
0.08
colorectal cancer
0.04
pancreatic neoplasm
0.04
familial pancreatic carcinoma
0.04
lung adenocarcinoma
0.04
lung cancer
0.04
lung carcinoma
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

T-complex protein 1 subunit theta

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638)