CD19

Chr 16p11.2

CD19 molecule

MANE:: ENST00000538922.8

OMIM: 107265 ↗NCBI: 930 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

CD19 · P15391

v62025-08-01

Predicted Aligned Error matrix for CD19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.2/ 100

Low

556 residues

Confidence breakdown

Very high(≥ 90)24%
Confident(70–90)19%
Low(50–70)12%
Very low(< 50)45%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

immunodeficiency, common variable, 3
0.67
diffuse large B-cell lymphoma
0.62
common variable immunodeficiency
0.60
acute lymphoblastic leukemia
0.59
neuromyelitis optica
0.58
mantle cell lymphoma
0.55
follicular lymphoma
0.54
neoplasm
0.53
B-cell acute lymphoblastic leukemia
0.52
agammaglobulinemia
0.47

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

B-lymphocyte antigen CD19

Functions as a coreceptor for the B-cell antigen receptor complex (BCR) on B-lymphocytes (PubMed:29523808). Decreases the threshold for activation of downstream signaling pathways and for triggering B-cell responses to antigens (PubMed:1373518, PubMed:16672701, PubMed:2463100). Activates signaling pathways that lead to the activation of phosphatidylinositol 3-kinase and the mobilization of intracellular Ca(2+) stores (PubMed:12387743, PubMed:16672701, PubMed:9317126, PubMed:9382888). Is not required for early steps during B cell differentiation in the blood marrow (PubMed:9317126). Required for normal differentiation of B-1 cells (By similarity). Required for normal B cell differentiation and proliferation in response to antigen challenges (PubMed:1373518, PubMed:2463100). Required for normal levels of serum immunoglobulins, and for production of high-affinity antibodies in response to antigen challenge (PubMed:12387743, PubMed:16672701, PubMed:9317126)

Curated MONDO disease pages that list CD19 among their top associated genes.

diffuse large B-cell lymphomaRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with CD19