CD207

Chr 2p13.3

CD207 molecule

Aliases:: Langerin, CLEC4K
MANE:: ENST00000410009.5

OMIM: 604862 ↗NCBI: 50489 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CD207 · Q9UJ71

v62025-08-01

Predicted Aligned Error matrix for CD207 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.6/ 100

Confident

328 residues

Confidence breakdown

Very high(≥ 90)73%
Confident(70–90)11%
Low(50–70)5%
Very low(< 50)11%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

Birbeck granule deficiency
0.48
seasonal allergic rhinitis
0.43
narcolepsy-cataplexy syndrome
0.35
atopic eczema
0.34
spinal cord injury
0.26
liver disorder
0.20
neurodegenerative disease
0.17
chronic obstructive pulmonary disease
0.09
Alzheimer disease
0.08
infection
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

C-type lectin domain family 4 member K

Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs); is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation