AlphaFold predicted structure
CD40 · P25942
Mean pLDDT
81.2/ 100
Confident
277 residues
Confidence breakdown
- Very high(≥ 90)60%
- Confident(70–90)9%
- Low(50–70)18%
- Very low(< 50)13%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CD40
Chr 20q13.12CD40 molecule
- Aliases:
- p50, Bp50
- MANE:
- ENST00000372285.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BIALLELIC, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomalCytopenia - NOT Fanconi anaemia
BIALLELIC, autosomal or pseudoautosomalFamilial Meniere Disease
Disease associations (Open Targets)
hyper-IgM syndrome type 3
0.80rheumatoid arthritis
0.60Graves disease
0.57inflammatory bowel disease
0.50Crohn disease
0.50multiple sclerosis
0.48bipolar disorder
0.48Kawasaki disease
0.45thyrotoxicosis
0.45mathematical ability
0.45
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Tumor necrosis factor receptor superfamily member 5
Receptor for TNFSF5/CD40LG (PubMed:31331973). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity)
Diseases associated with CD40
Curated MONDO disease pages that list CD40 among their top associated genes.