CD40 ligand
Annotations refreshed 10 hours ago.
Diagnostic Grade (Green)
COVID-19 research
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesGastrointestinal epithelial barrier disorders
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesInfantile enterocolitis & monogenic inflammatory bowel disease
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesPrimary immunodeficiency or monogenic inflammatory bowel disease
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesFetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesCytopenia - NOT Fanconi anaemia
X-LINKED: hemizygous mutation in males, biallelic mutations in femaleshyper-IgM syndrome type 1
X-linked hyper-IgM syndrome
hyper-IgM syndrome
hereditary disease
systemic lupus erythematosus
common variable immunodeficiency
Sjogren syndrome
neurodegenerative disease
ulcerative colitis
sarcoidosis
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
CD40 ligand
Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity)
Curated MONDO disease pages that list CD40LG among their top associated genes.
CD40LG · P29965
Mean pLDDT
82.6/ 100
Confident
261 residues
Confidence breakdown
AlphaFold (Jumper et al., 2021) · CC BY 4.0
