CD59

Chr 11p13

CD59 molecule (CD59 blood group)

Aliases:: 16.3A5, EJ16, EJ30, EL32, G344
MANE:: ENST00000642928.2

OMIM: 107271 ↗NCBI: 966 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

CD59 · P13987

v62025-08-01

Predicted Aligned Error matrix for CD59 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

79.3/ 100

Confident

128 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)17%
Low(50–70)25%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Cytopenias and congenital anaemias
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy
BIALLELIC, autosomal or pseudoautosomal
Hereditary neuropathy or pain disorder
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal
Rare anaemia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

primary CD59 deficiency
0.77
paroxysmal nocturnal hemoglobinuria
0.50
complement deficiency
0.46
dyskeratosis congenita, X-linked
0.37
dyskeratosis congenita
0.37
hereditary disease
0.18
neoplasm
0.10
neuromyelitis optica
0.10
cancer
0.10
breast cancer
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

CD59 glycoprotein

Potent inhibitor of the complement membrane attack complex (MAC) action, which protects human cells from damage during complement activation (PubMed:11882685, PubMed:1698710, PubMed:2475111, PubMed:2475570, PubMed:2606909, PubMed:9053451). Acts by binding to the beta-haipins of C8 (C8A and C8B) components of the assembling MAC, forming an intermolecular beta-sheet that prevents incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore (PubMed:11882685, PubMed:1698710, PubMed:36797260)