CD70

Chr 19p13.3

CD70 molecule

Aliases:: CD27L, CD27-L
MANE:: ENST00000245903.4

OMIM: 602840 ↗NCBI: 970 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CD70 · P32970

v62025-08-01

Predicted Aligned Error matrix for CD70 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

83.2/ 100

Confident

193 residues

Confidence breakdown

Very high(≥ 90)54%
Confident(70–90)24%
Low(50–70)16%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

severe combined immunodeficiency due to CD70 deficiency
0.66
combined immunodeficiency
0.46
severe combined immunodeficiency
0.46
non-Hodgkin lymphoma
0.33
hematopoietic and lymphoid cell neoplasm
0.32
neurodegenerative disease
0.24
hereditary disease
0.19
neoplasm
0.15
acute myeloid leukemia
0.13
renal cell carcinoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

CD70 antigen

Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864)