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CD79B

Chr 17q23.3

CD79b molecule

Aliases:
B29, Ig-beta, Igbeta
MANE:
ENST00000006750.8
OMIM: 147245 ↗NCBI: 974 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

  • COVID-19 research

    BIALLELIC, autosomal or pseudoautosomal

  • Primary immunodeficiency or monogenic inflammatory bowel disease

    BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

  • diffuse large B-cell lymphoma

    0.75

  • isolated agammaglobulinemia

    0.64

  • autosomal agammaglobulinemia

    0.47

  • agammaglobulinemia

    0.47

  • B-cell non-Hodgkin lymphoma

    0.44

  • neoplasm

    0.41

  • diffuse large B-cell lymphoma of the central nervous system

    0.39

  • primary central nervous system lymphoma

    0.38

  • breast diffuse large B-cell lymphoma

    0.37

  • lymphoid neoplasm

    0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

B-cell antigen receptor complex-associated protein beta chain

Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation

Diseases associated with CD79B

Curated MONDO disease pages that list CD79B among their top associated genes.

Data sources: HGNC (CC BY 4.0), AlphaFold (CC BY 4.0, Jumper et al. Nature 2021), Genomics England PanelApp (CC BY 4.0), ClinGen, Open Targets (CC0), UniProt.

Not for sole clinical decision-making. Always verify against primary sources.