CD96

Chr 3q13.13-q13.2

CD96 molecule

Aliases:: TACTILE
MANE:: ENST00000352690.9

OMIM: 606037 ↗NCBI: 10225 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CD96 · P40200

v62025-08-01

Predicted Aligned Error matrix for CD96 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

64.9/ 100

Low

585 residues

Confidence breakdown

Very high(≥ 90)19%
Confident(70–90)32%
Low(50–70)17%
Very low(< 50)32%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Limb disorders
Rare syndromic craniosynostosis or isolated multisuture synostosis
Skeletal dysplasia

Disease associations (Open Targets)

C syndrome
0.62
tooth disorder
0.27
diaphragm disorder
0.22
Abnormal erythrocyte morphology
0.22
lacrimal apparatus disorder
0.21
adolescent idiopathic scoliosis
0.21
response to TNF antagonist
0.14
neoplasm
0.12
acute myeloid leukemia
0.10
central nervous system cancer
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

T-cell surface protein tactile

May be involved in adhesive interactions of activated T and NK cells during the late phase of the immune response. Promotes NK cell-target adhesion by interacting with PVR present on target cells. May function at a time after T and NK cells have penetrated the endothelium using integrins and selectins, when they are actively engaging diseased cells and moving within areas of inflammation