CDC14A

Chr 1p21.2

cell division cycle 14A

Aliases:: Cdc14A1, Cdc14A2, cdc14, DFNB105
MANE:: ENST00000336454.5

OMIM: 603504 ↗NCBI: 8556 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDC14A · Q9UNH5

v62025-08-01

Predicted Aligned Error matrix for CDC14A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.5/ 100

Confident

594 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)6%
Low(50–70)4%
Very low(< 50)37%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hearing loss, autosomal recessive
0.68
deafness
0.64
Non-syndromic genetic deafness
0.39
hearing impairment and infertile male syndrome
0.37
nonsyndromic genetic hearing loss
0.37
neurodegenerative disease
0.36
Abnormality of the ear
0.34
Sensorineural hearing impairment
0.34
ear malformation
0.33
autoimmune disorder of central nervous system
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Dual specificity protein phosphatase CDC14A

Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958)