AlphaFold predicted structure
CDC42 · P60953
Mean pLDDT
93.5/ 100
Very high
191 residues
Confidence breakdown
- Very high(≥ 90)85%
- Confident(70–90)8%
- Low(50–70)6%
- Very low(< 50)1%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
CDC42
Chr 1p36.12cell division cycle 42
- Aliases:
- G25K, CDC42Hs
- MANE:
- ENST00000656825.1
Annotations refreshed 10 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Bleeding and platelet disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownCOVID-19 research
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownDDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownFetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedInherited bleeding disorders
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedPrimary immunodeficiency or monogenic inflammatory bowel disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFetal hydrops
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
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Disease associations (Open Targets)
macrothrombocytopenia-lymphedema-developmental delay-facial dysmorphism-camptodactyly syndrome
0.77hereditary disease
0.48hemophagocytic syndrome
0.46exanthem
0.46Skin rash
0.46neurodevelopmental disorder
0.46diverticular disease
0.41Neurodevelopmental abnormality
0.40Abnormal facial shape
0.40Abnormality of the immune system
0.40
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cell division control protein 42 homolog
Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317, PubMed:22843693). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. In podocytes, facilitates filopodia and podosomes formation upon DOCK11-activation (PubMed:33523862). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). Upon activation by PLEKHG4B, involved in actin cytoskeletal remodeling during epithelial cell-cell junction formation (PubMed:33310911). Negatively regulates polymerization of SEPTIN12, as a result may be involved in spermatogenesis (PubMed:30189608)