CDC45

Chr 22q11.21

cell division cycle 45

MANE:: ENST00000263201.7

OMIM: 603465 ↗NCBI: 8318 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDC45 · O75419

v62025-08-01

Predicted Aligned Error matrix for CDC45 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

92.6/ 100

Very high

566 residues

Confidence breakdown

Very high(≥ 90)85%
Confident(70–90)10%
Low(50–70)2%
Very low(< 50)2%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Rare syndromic craniosynostosis or isolated multisuture synostosis
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal
Clefting
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Ear-patella-short stature syndrome
0.80
hereditary disease
0.20
microcephaly
0.11
hepatocellular carcinoma
0.11
androgen insensitivity syndrome
0.11
cancer
0.09
neoplasm
0.08
acute myeloid leukemia
0.08
colorectal carcinoma
0.08
gastric cancer
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cell division control protein 45 homolog

Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built