CDC6

Chr 17q21.2

cell division cycle 6

MANE:: ENST00000209728.9

OMIM: 602627 ↗NCBI: 990 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CDC6 · Q99741

v62025-08-01

Predicted Aligned Error matrix for CDC6 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.7/ 100

Low

560 residues

Confidence breakdown

Very high(≥ 90)25%
Confident(70–90)36%
Low(50–70)9%
Very low(< 50)30%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Deafness and congenital structural abnormalities
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
IUGR and IGF abnormalities
BIALLELIC, autosomal or pseudoautosomal
Monogenic short stature
BIALLELIC, autosomal or pseudoautosomal
Severe microcephaly
BIALLELIC, autosomal or pseudoautosomal
Skeletal dysplasia
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Ear-patella-short stature syndrome
0.71
neurodegenerative disease
0.46
Meier-Gorlin syndrome
0.37
hepatocellular carcinoma
0.11
microcephaly
0.11
neoplasm
0.11
cancer
0.11
colorectal carcinoma
0.09
breast carcinoma
0.09
breast cancer
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

DNA replication factor CDC6

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated