CDCA7

Chr 2q31.1

cell division cycle associated 7

Aliases:: FLJ14736, JPO1
MANE:: ENST00000306721.8

OMIM: 609937 ↗NCBI: 83879 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDCA7 · Q9BWT1

v62025-08-01

Predicted Aligned Error matrix for CDCA7 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

68.8/ 100

Low

371 residues

Confidence breakdown

Very high(≥ 90)33%
Confident(70–90)14%
Low(50–70)23%
Very low(< 50)31%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

COVID-19 research
BIALLELIC, autosomal or pseudoautosomal
Primary immunodeficiency or monogenic inflammatory bowel disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ICF syndrome
0.61
prostate carcinoma
0.51
Recurrent respiratory infections
0.46
Abnormal intestine morphology
0.46
immunodeficiency-centromeric instability-facial anomalies syndrome
0.46
breast carcinoma
0.42
breast cancer
0.42
androgenetic alopecia
0.42
alopecia
0.36
ovarian carcinoma
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cell division cycle-associated protein 7

Participates in MYC-mediated cell transformation and apoptosis; induces anchorage-independent growth and clonogenicity in lymphoblastoid cells. Insufficient to induce tumorigenicity when overexpressed but contributes to MYC-mediated tumorigenesis (PubMed:11598121, PubMed:15994934, PubMed:23166294). Also functions as a critical cofactor for the chromatin remodeler HELLS, facilitating its recruitment to specific genomic regions to maintain DNA methylation patterns and heterochromatin integrity. Recognizes hemimethylated CpG within nucleosomes where it recruits HELLS to remodel chromatin and facilitate access of de novo DNA methyltransferases to heterochromatic regions, enabling proper establishment of DNA methylation patterns (PubMed:30307408, PubMed:39178260). May play a role as transcriptional regulator (PubMed:16580749)