CDCA8

Chr 1p34.3

cell division cycle associated 8

Aliases:: FLJ12042, MESRGP, BOR, DasraB
MANE:: ENST00000373055.6

OMIM: 609977 ↗NCBI: 55143 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDCA8 · Q53HL2

v62025-08-01

Predicted Aligned Error matrix for CDCA8 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

67.9/ 100

Low

280 residues

Confidence breakdown

Very high(≥ 90)19%
Confident(70–90)36%
Low(50–70)15%
Very low(< 50)29%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Congenital hypothyroidism
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

Neutrophil inclusion bodies
0.26
hypothyroidism, congenital, nongoitrous, 2
0.19
congenital hypothyroidism
0.19
glomerulonephritis
0.16
hepatocellular carcinoma
0.12
neoplasm
0.11
breast cancer
0.10
central nervous system cancer
0.09
posterior cortical atrophy
0.08
glioma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Borealin

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment