CDH11

Chr 16q21

cadherin 11

Aliases:: OB, CAD11
MANE:: ENST00000268603.9

OMIM: 600023 ↗NCBI: 1009 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDH11 · P55287

v62025-08-01

Predicted Aligned Error matrix for CDH11 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

77.7/ 100

Confident

796 residues

Confidence breakdown

Very high(≥ 90)49%
Confident(70–90)24%
Low(50–70)7%
Very low(< 50)20%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

Teebi hypertelorism syndrome 2
0.75
Elsahy-Waters syndrome
0.71
Branchio-skeleto-genital syndrome
0.64
open-angle glaucoma
0.48
esophageal adenocarcinoma
0.38
pancreatic ductal adenocarcinoma
0.38
aneurysmal bone cyst
0.38
Teebi hypertelorism syndrome
0.37
Hypertelorism, Teebi type
0.37
gastric carcinoma
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cadherin-11

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. Required for proper focal adhesion assembly (PubMed:33811546). Involved in the regulation of cell migration (PubMed:33811546)

Curated MONDO disease pages that list CDH11 among their top associated genes.

esophageal adenocarcinomaRare

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Disease associations (Open Targets)

Protein function (UniProt)

Diseases associated with CDH11