CDH4

Chr 20q13.33

cadherin 4

Aliases:: R-CAD
MANE:: ENST00000614565.5

OMIM: 603006 ↗NCBI: 1002 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

CDH4 · P55283

v62025-08-01

Predicted Aligned Error matrix for CDH4 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.8/ 100

Confident

916 residues

Confidence breakdown

Very high(≥ 90)50%
Confident(70–90)25%
Low(50–70)6%
Very low(< 50)19%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Structural eye disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

alcohol drinking
0.48
smoking initiation
0.42
myopathy
0.37
preeclampsia
0.35
liver disorder
0.35
depressive disorder
0.33
mathematical ability
0.33
major depressive disorder
0.33
placenta praevia
0.33
pyogenic granuloma
0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cadherin-4

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May play an important role in retinal development