CDHR1

Chr 10q23.1

cadherin related family member 1

Aliases:: KIAA1775, CORD15, RP65
MANE:: ENST00000623527.4

OMIM: 609502 ↗NCBI: 92211 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDHR1 · Q96JP9

v62025-08-01

Predicted Aligned Error matrix for CDHR1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

78.8/ 100

Confident

859 residues

Confidence breakdown

Very high(≥ 90)46%
Confident(70–90)30%
Low(50–70)8%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
BIALLELIC, autosomal or pseudoautosomal
Glaucoma (developmental)
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

cone-rod dystrophy 15
0.71
retinitis pigmentosa
0.66
Cone rod dystrophy
0.66
retinitis pigmentosa 65
0.63
cone-rod dystrophy
0.56
Retinal dystrophy
0.56
macular dystrophy, retinal, 5
0.47
Rod-cone dystrophy
0.38
autosomal recessive cone rod dystrophy
0.37
eye disorder
0.37

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cadherin-related family member 1

Potential calcium-dependent cell-adhesion protein. May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity)