CDK10

Chr 16q24.3

cyclin dependent kinase 10

Aliases:: PISSLRE
MANE:: ENST00000353379.12

OMIM: 603464 ↗NCBI: 8558 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CDK10 · Q15131

v62025-08-01

Predicted Aligned Error matrix for CDK10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.9/ 100

Confident

360 residues

Confidence breakdown

Very high(≥ 90)62%
Confident(70–90)25%
Low(50–70)6%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

Al Kaissi syndrome
0.72
neurodegenerative disease
0.53
hereditary disease
0.45
Intellectual disability
0.37
Global developmental delay
0.34
Abnormal brain morphology
0.33
melanoma
0.13
hair color
0.13
hypertensive disorder
0.10
small cell lung carcinoma
0.10

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclin-dependent kinase 10

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) (PubMed:24218572). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling (PubMed:27104747)