CDK19

Chr 6q21

cyclin dependent kinase 19

Aliases:: KIAA1028, bA346C16.3
MANE:: ENST00000368911.8

OMIM: 614720 ↗NCBI: 23097 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDK19 · Q9BWU1

v62025-08-01

Predicted Aligned Error matrix for CDK19 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.6/ 100

Confident

502 residues

Confidence breakdown

Very high(≥ 90)56%
Confident(70–90)10%
Low(50–70)8%
Very low(< 50)27%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Early onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

developmental and epileptic encephalopathy, 87
0.79
hereditary disease
0.41
undetermined early-onset epileptic encephalopathy
0.37
diabetes mellitus
0.25
alcohol drinking
0.24
urolithiasis
0.24
risk-taking behaviour
0.23
placental abruption
0.22
bronchial disorder
0.22
self-injurious ideation
0.20

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclin-dependent kinase 19

Component of the Mediator complex, a transcriptional coactivator required for regulated expression of nearly all RNA polymerase II-dependent genes. Acts as a molecular bridge between gene-specific regulatory proteins and the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters through direct interactions with transcriptional regulators and serves as a scaffold for assembly of the pre-initiation complex with RNA polymerase II and general transcription factors. Contributes to phosphorylation of transcription factors and other substrates, including RNA polymerase II and the Notch1 intracellular domain (ICN1), thereby modulating gene expression programs (PubMed:25344755, PubMed:28855340, PubMed:29440396). Plays a role together with CDK8 in normal macrophage differentiation (By similarity)