AlphaFold predicted structure
CDKN1B · P46527
Mean pLDDT
69.3/ 100
Low
198 residues
Confidence breakdown
- Very high(≥ 90)33%
- Confident(70–90)8%
- Low(50–70)36%
- Very low(< 50)23%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
CDKN1B
Chr 12p13.1cyclin dependent kinase inhibitor 1B
- Aliases:
- KIP1, P27KIP1
- MANE:
- ENST00000228872.9
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Adult solid tumours cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedAdult solid tumours for rare disease
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedEndocrine neoplasia
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedFamilial hyperparathyroidism or hypocalciuric hypercalcaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownMultiple endocrine tumours
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedNeuroendocrine cancer pertinent cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedThyroid cancer pertinent cancer susceptibility
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedCOVID-19 research
Unknown
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Disease associations (Open Targets)
multiple endocrine neoplasia type 4
0.79prostate carcinoma
0.56Inherited cancer-predisposing syndrome
0.55hereditary neoplastic syndrome
0.55thyroid gland carcinoma
0.55neurodegenerative disease
0.54pituitary gland adenoma
0.51thyroid cancer
0.51type 2 diabetes mellitus
0.50prostate adenocarcinoma
0.46
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Cyclin-dependent kinase inhibitor 1B
Important regulator of cell cycle progression. Inhibits the kinase activity of CDK2 bound to cyclin A, but has little inhibitory activity on CDK2 bound to SPDYA (PubMed:28666995). Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Forms a complex with cyclin type D-CDK4 complexes and is involved in the assembly, stability, and modulation of CCND1-CDK4 complex activation. Acts either as an inhibitor or an activator of cyclin type D-CDK4 complexes depending on its phosphorylation state and/or stoichiometry
Diseases associated with CDKN1B
Curated MONDO disease pages that list CDKN1B among their top associated genes.