CDKN2C

Chr 1p32.3

cyclin dependent kinase inhibitor 2C

Aliases:: INK4C, p18
MANE:: ENST00000371761.4

OMIM: 603369 ↗NCBI: 1031 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CDKN2C · P42773

v62025-08-01

Predicted Aligned Error matrix for CDKN2C — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

91.9/ 100

Very high

168 residues

Confidence breakdown

Very high(≥ 90)84%
Confident(70–90)8%
Low(50–70)2%
Very low(< 50)5%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Familial hyperparathyroidism or hypocalciuric hypercalcaemia
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

neurodegenerative disease
0.54
plasma cell myeloma
0.38
anaplastic oligodendroglioma
0.37
parathyroid gland carcinoma
0.37
brain glioblastoma
0.37
type 2 diabetes mellitus
0.37
cataract
0.35
diabetes mellitus
0.34
glioma
0.34
prostate carcinoma
0.32

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cyclin-dependent kinase 4 inhibitor C

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB