CDON

Chr 11q24.2

cell adhesion associated, oncogene regulated

Aliases:: ORCAM, CDO, CDON1, Ihog
MANE:: ENST00000531738.6

OMIM: 608707 ↗NCBI: 50937 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CDON · Q4KMG0

v62025-08-01

Predicted Aligned Error matrix for CDON — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

62.0/ 100

Low

1,287 residues

Confidence breakdown

Very high(≥ 90)10%
Confident(70–90)42%
Low(50–70)12%
Very low(< 50)37%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Holoprosencephaly
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Intellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Structural eye disease
BIALLELIC, autosomal or pseudoautosomal
Pituitary hormone deficiency
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown
Familial Neural Tube Defects
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

holoprosencephaly
0.80
pituitary stalk interruption syndrome
0.46
alobar holoprosencephaly
0.38
microform holoprosencephaly
0.38
septopreoptic holoprosencephaly
0.38
semilobar holoprosencephaly
0.37
midline interhemispheric variant of holoprosencephaly
0.37
lobar holoprosencephaly
0.37
coloboma
0.26
benign thyroid gland neoplasm
0.24

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cell adhesion molecule-related/down-regulated by oncogenes

Together with BOC, forms a coreceptor required for sonic hedgehog (SHH) handoff to its patched receptor (PTCH1 or PTCH2), thereby allowing activation of the smoothened signaling pathway (By similarity). Binds to the dually lipid-modified Sonic hedgehog protein N-product (ShhN) downstream of SCUBE2 carrier and promotes its release to GAS1 (By similarity). ShhN is then directly transferred to patched receptor by GAS1 (By similarity). May also mediate cell-cell interactions between muscle precursor cells, promoting differentiation of myogenic cells (By similarity)