CFAP74

Chr 1p36.33

cilia and flagella associated protein 74

Aliases:: FLJ45476
MANE:: ENST00000682832.2

OMIM: 620187 ↗NCBI: 85452 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CFAP74 · Q9C0B2

v62025-08-01

Predicted Aligned Error matrix for CFAP74 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

69.3/ 100

Low

1,584 residues

Confidence breakdown

Very high(≥ 90)8%
Confident(70–90)57%
Low(50–70)12%
Very low(< 50)23%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Respiratory ciliopathies including non-CF bronchiectasis
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

ciliary dyskinesia, primary, 49, without situs inversus
0.68
primary ciliary dyskinesia
0.37
endocrine system disorder
0.28
influenza A (H1N1)
0.26
Abnormal male internal genitalia morphology
0.24
placental abruption
0.24
cholelithiasis
0.22
kidney failure
0.21
ovarian dysfunction
0.18
arthropathy
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cilia- and flagella-associated protein 74

As part of the central apparatus of the cilium axoneme may play a role in cilium movement. May play an important role in sperm architecture and function