AlphaFold predicted structure
CFHR2 · P36980
Mean pLDDT
90.6/ 100
Very high
270 residues
Confidence breakdown
- Very high(≥ 90)80%
- Confident(70–90)13%
- Low(50–70)1%
- Very low(< 50)7%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CFHR2
Chr 1q31.3complement factor H related 2
- Aliases:
- FHR2
- MANE:
- ENST00000367415.8
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomalMembranoproliferative glomerulonephritis including C3 glomerulopathy
BOTH monoallelic and biallelic, autosomal or pseudoautosomalPrimary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
age-related macular degeneration
0.50complement 3 glomerulopathy
0.47complement deficiency
0.37macular degeneration
0.33pathological myopia
0.11myopia
0.11mirror movements 2
0.07familial congenital mirror movements
0.07mirror movements 4
0.07Benign familial chorea
0.07
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Complement factor H-related protein 2
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism
Diseases associated with CFHR2
Curated MONDO disease pages that list CFHR2 among their top associated genes.