AlphaFold predicted structure
CFHR4 · Q92496
Mean pLDDT
87.6/ 100
Confident
578 residues
Confidence breakdown
- Very high(≥ 90)51%
- Confident(70–90)45%
- Low(50–70)1%
- Very low(< 50)3%
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AlphaFold (Jumper et al., 2021) · CC BY 4.0
CFHR4
Chr 1q31.3complement factor H related 4
- Aliases:
- FHR-4, FHR4
- MANE:
- ENST00000608469.6
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
COVID-19 research
BOTH monoallelic and biallelic, autosomal or pseudoautosomalAtypical haemolytic uraemic syndrome
UnknownPrimary immunodeficiency or monogenic inflammatory bowel disease
BOTH monoallelic and biallelic, autosomal or pseudoautosomal
Disease associations (Open Targets)
age-related macular degeneration
0.49retinal disorder
0.41macular degeneration
0.41complement deficiency
0.37neurodegenerative disease
0.29placental abruption
0.24kidney disorder
0.12hepatocellular carcinoma
0.10degeneration of macula and posterior pole
0.10neoplasm
0.09
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Complement factor H-related protein 4
Involved in complement regulation. Can associate with lipoproteins and may play a role in lipid metabolism