CHAF1A

Chr 19p13.3

chromatin assembly factor 1 subunit A

Aliases:: CAF1P150, CAF1B, CAF-1, CAF1, P150
MANE:: ENST00000301280.10

OMIM: 601246 ↗NCBI: 10036 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CHAF1A · Q13111

v62025-08-01

Predicted Aligned Error matrix for CHAF1A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

57.8/ 100

Low

956 residues

Confidence breakdown

Very high(≥ 90)6%
Confident(70–90)29%
Low(50–70)16%
Very low(< 50)49%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Fetal anomalies
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Paediatric disorders - additional genes
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

craniofacial microsomia
0.45
neurodegenerative disease
0.44
Abnormality of the skeletal system
0.19
neoplasm
0.10
gastric cancer
0.10
hepatocellular carcinoma
0.09
non-small cell lung carcinoma
0.08
placenta praevia
0.08
cancer
0.08
neuroblastoma
0.08

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Chromatin assembly factor 1 subunit A

Acts as a component of the histone chaperone complex chromatin assembly factor 1 (CAF-1), which assembles histone octamers onto DNA during replication and repair. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci