AlphaFold predicted structure
CHRDL1 · Q9BU40
Mean pLDDT
69.6/ 100
Low
456 residues
Confidence breakdown
- Very high(≥ 90)13%
- Confident(70–90)50%
- Low(50–70)8%
- Very low(< 50)29%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CHRDL1
Chr Xq23chordin like 1
- Aliases:
- NRLN1, CHL
- MANE:
- ENST00000372042.6
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
Corneal abnormalities
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesDDG2P
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesStructural eye disease
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesFetal anomalies
X-LINKED: hemizygous mutation in males, biallelic mutations in femalesIntellectual disability
X-LINKED: hemizygous mutation in males, biallelic mutations in females
Disease associations (Open Targets)
isolated congenital megalocornea
0.71megalocornea
0.63spinal stenosis
0.29Inguinal hernia
0.22ventral hernia
0.22hereditary disease
0.19low grade glioma
0.18coronary artery disorder
0.17Umbilical hernia
0.16response to surgery
0.16
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Chordin-like protein 1
Antagonizes the function of BMP4 by binding to it and preventing its interaction with receptors. Alters the fate commitment of neural stem cells from gliogenesis to neurogenesis. Contributes to neuronal differentiation of neural stem cells in the brain by preventing the adoption of a glial fate. May play a crucial role in dorsoventral axis formation. May play a role in embryonic bone formation (By similarity). May also play an important role in regulating retinal angiogenesis through modulation of BMP4 actions in endothelial cells. Plays a role during anterior segment eye development