AlphaFold predicted structure
CHRM3 · P20309
Mean pLDDT
66.7/ 100
Low
590 residues
Confidence breakdown
- Very high(≥ 90)32%
- Confident(70–90)22%
- Low(50–70)8%
- Very low(< 50)39%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CHRM3
Chr 1q43cholinergic receptor muscarinic 3
- Aliases:
- m3AChR
- MANE:
- ENST00000676153.1
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
CAKUT
BIALLELIC, autosomal or pseudoautosomalUnexplained kidney failure in young people
BIALLELIC, autosomal or pseudoautosomalUnexplained young onset end-stage renal disease - additional genes
BIALLELIC, autosomal or pseudoautosomalFetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
prune belly syndrome
0.70chronic obstructive pulmonary disease
0.67gastrointestinal disease
0.66Hyperhidrosis
0.63seasonal allergic rhinitis
0.62overactive bladder
0.61asthma
0.61Urinary incontinence
0.60urgency urinary incontinence
0.59pulmonary emphysema
0.59
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Muscarinic acetylcholine receptor M3
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover
Diseases associated with CHRM3
Curated MONDO disease pages that list CHRM3 among their top associated genes.