CLCA2

Chr 1p22.3

chloride channel accessory 2

Aliases:: CLCRG2
MANE:: ENST00000370565.5

OMIM: 604003 ↗NCBI: 9635 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CLCA2 · Q9UQC9

v62025-08-01

Predicted Aligned Error matrix for CLCA2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

86.6/ 100

Confident

943 residues

Confidence breakdown

Very high(≥ 90)64%
Confident(70–90)23%
Low(50–70)6%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Progressive cardiac conduction disease
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknown

Disease associations (Open Targets)

Hallux valgus
0.29
heart conduction disease
0.18
cervical cancer
0.08
cervical carcinoma
0.08
urolithiasis
0.08
alcohol drinking
0.08
nasopharyngeal carcinoma
0.07
early-onset non-syndromic cataract
0.07
Leber congenital amaurosis
0.06
retinitis pigmentosa
0.06

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Calcium-activated chloride channel regulator 2

Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4