CLDN10

Chr 13q32.1

claudin 10

Aliases:: OSP-L, CPETRL3
MANE:: ENST00000299339.3

OMIM: 617579 ↗NCBI: 9071 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CLDN10 · P78369

v62025-08-01

Predicted Aligned Error matrix for CLDN10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.1/ 100

Confident

228 residues

Confidence breakdown

Very high(≥ 90)51%
Confident(70–90)23%
Low(50–70)10%
Very low(< 50)16%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Renal tubulopathies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

helix rolling
0.71
Abnormality of the skeletal system
0.38
nephrolithiasis
0.32
diabetes mellitus
0.30
alcohol drinking
0.27
urolithiasis
0.26
polyarteritis nodosa
0.22
hereditary disease
0.19
gout
0.18
bladder calculus
0.15

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Claudin-10

Forms paracellular channels: polymerizes in tight junction strands with cation- and anion-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability