CLDN14

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Monogenic hearing loss

  BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

• hearing loss, autosomal recessive

  0.70

• deafness

  0.54

• nephrolithiasis

  0.50

• gout

  0.45

• vein of Galen aneurysm

  0.45

• Hearing impairment

  0.44

• ureterolithiasis

  0.43

• urolithiasis

  0.43

• bladder calculus

  0.41

• nonsyndromic genetic hearing loss

  0.40

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with CLDN14

Curated MONDO disease pages that list CLDN14 among their top associated genes.

• urolithiasisRare