CLEC16A

Chr 16p13.13

C-type lectin domain containing 16A

Aliases:: Gop-1
MANE:: ENST00000409790.6

OMIM: 611303 ↗NCBI: 23274 ↗Ensembl ↗

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Predicted protein structure

AlphaFold predicted structure

CLEC16A · Q2KHT3

v62025-08-01

Predicted Aligned Error matrix for CLEC16A — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.8/ 100

Confident

1,053 residues

Confidence breakdown

Very high(≥ 90)44%
Confident(70–90)20%
Low(50–70)5%
Very low(< 50)32%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

hypothyroidism
0.41
asthma
0.37
type 1 diabetes mellitus
0.36
thyroid gland disorder
0.34
systemic lupus erythematosus
0.34
nephrotic syndrome
0.33
multiple sclerosis
0.32
atopic eczema
0.31
dermatitis
0.30
acne
0.30

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein CLEC16A

Regulator of mitophagy through the upstream regulation of the RNF41/NRDP1-PRKN pathway. Mitophagy is a selective form of autophagy necessary for mitochondrial quality control. The RNF41/NRDP1-PRKN pathway regulates autophagosome-lysosome fusion during late mitophagy. May protect RNF41/NRDP1 from proteasomal degradation, RNF41/NRDP1 which regulates proteasomal degradation of PRKN. Plays a key role in beta cells functions by regulating mitophagy/autophagy and mitochondrial health