CLEC3B

Chr 3p21.31

C-type lectin domain family 3 member B

Aliases:: TN
MANE:: ENST00000296130.5

OMIM: 187520 ↗NCBI: 7123 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CLEC3B · P05452

v62025-08-01

Predicted Aligned Error matrix for CLEC3B — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

87.9/ 100

Confident

202 residues

Confidence breakdown

Very high(≥ 90)77%
Confident(70–90)5%
Low(50–70)7%
Very low(< 50)10%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Retinal disorders
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

Disease associations (Open Targets)

macular dystrophy, retinal, 4
0.45
neurodegenerative disease
0.31
inborn disorder of amino acid metabolism
0.25
Parkinson disease
0.23
Alzheimer disease
0.22
lysosomal storage disease
0.22
multiple sclerosis
0.22
autoimmune disorder of central nervous system
0.16
hepatocellular carcinoma
0.11
neoplasm
0.11

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Tetranectin

Tetranectin binds to plasminogen and to isolated kringle 4. May be involved in the packaging of molecules destined for exocytosis. Plays a role in retinal function (PubMed:35331648)