CLEC4M

Chr 19p13.2

C-type lectin domain family 4 member M

Aliases:: L-SIGN, CD209L1, HP10347, DC-SIGNR, LSIGN
MANE:: ENST00000327325.10

OMIM: 605872 ↗NCBI: 10332 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CLEC4M · Q9H2X3

v62025-08-01

Predicted Aligned Error matrix for CLEC4M — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

70.4/ 100

Confident

399 residues

Confidence breakdown

Very high(≥ 90)31%
Confident(70–90)12%
Low(50–70)41%
Very low(< 50)17%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

COVID-19 research
Unknown

Disease associations (Open Targets)

venous thromboembolism
0.35
coronary artery disorder
0.34
ischemic stroke
0.34
hepatocellular carcinoma
0.13
contact dermatitis
0.12
infection
0.11
non-small cell lung carcinoma
0.09
neoplasm
0.09
colonic neoplasm
0.09
malignant colon neoplasm
0.09

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

C-type lectin domain family 4 member M

Probable pathogen-recognition receptor involved in peripheral immune surveillance in liver. May mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. Is a receptor for ICAM3, probably by binding to mannose-like carbohydrates