CLMP

Chr 11q24.1

CXADR like cell adhesion molecule

Aliases:: ASAM, FLJ22415, ACAM
MANE:: ENST00000448775.4

OMIM: 611693 ↗NCBI: 79827 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CLMP · Q9H6B4

v62025-08-01

Predicted Aligned Error matrix for CLMP — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

76.8/ 100

Confident

373 residues

Confidence breakdown

Very high(≥ 90)53%
Confident(70–90)12%
Low(50–70)11%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Gastrointestinal neuromuscular disorders
BIALLELIC, autosomal or pseudoautosomal
Intestinal failure or congenital diarrhoea
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

congenital short bowel syndrome
0.69
congenital short bowel syndrome, autosomal recessive
0.67
intestinal pseudo-obstruction
0.44
disorder of ear
0.31
placental abruption
0.29
hemorrhoid
0.27
central nervous system cancer
0.26
hereditary disease
0.19
response to stimulus
0.17
ovarian neoplasm
0.17

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

CXADR-like membrane protein

May be involved in the cell-cell adhesion. May play a role in adipocyte differentiation and development of obesity. Is required for normal small intestine development