AlphaFold predicted structure
CLRN2 · A0PK11
Mean pLDDT
91.3/ 100
Very high
232 residues
Confidence breakdown
- Very high(≥ 90)80%
- Confident(70–90)12%
- Low(50–70)7%
- Very low(< 50)1%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CLRN2
Chr 4p15.32clarin 2
- Aliases:
- DFNB117
- MANE:
- ENST00000511148.2
Annotations refreshed 1 month ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Moderate Evidence (Amber)
Monogenic hearing loss
BIALLELIC, autosomal or pseudoautosomal
Disease associations (Open Targets)
hearing loss, autosomal recessive 117
0.52hearing loss disorder
0.51presbycusis
0.47Non-syndromic genetic deafness
0.20nonsyndromic genetic hearing loss
0.18Anisometropia
0.18alcohol drinking
0.18hypertensive disorder
0.18urolithiasis
0.18cervical carcinoma
0.11
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
Clarin-2
Plays a key role to hearing function. Required for normal organization and maintenance of the stereocilia bundle and for mechano-electrical transduction
Diseases associated with CLRN2
Curated MONDO disease pages that list CLRN2 among their top associated genes.