AlphaFold predicted structure
CNOT9 · Q92600
Mean pLDDT
92.4/ 100
Very high
299 residues
Confidence breakdown
- Very high(≥ 90)88%
- Confident(70–90)3%
- Low(50–70)3%
- Very low(< 50)6%
Open interactive 3D viewer
AlphaFold (Jumper et al., 2021) · CC BY 4.0
CNOT9
Chr 2q35CCR4-NOT transcription complex subunit 9
- Aliases:
- RCD1, RCD1+, CT129, CAF40
- MANE:
- ENST00000273064.11
Annotations refreshed 9 hours ago.
Predicted protein structure
Clinical relevance (Genomics England PanelApp)
Diagnostic Grade (Green)
DDG2P
MONOALLELIC, autosomal or pseudoautosomal, imprinted status unknownEarly onset or syndromic epilepsy
MONOALLELIC, autosomal or pseudoautosomal, NOT imprintedIntellectual disability
MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted
Disease associations (Open Targets)
melanoma
0.38epilepsy
0.37cutaneous melanoma
0.37Intellectual disability
0.37neuroendocrine neoplasm
0.27mouth disorder
0.11osteoarthritis, knee
0.10spinal stenosis
0.09Back pain
0.09Abnormality of the skeletal system
0.05
Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.
Protein function (UniProt)
CCR4-NOT transcription complex subunit 9
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in down-regulation of MYB- and JUN-dependent transcription. May play a role in cell differentiation (By similarity). Can bind oligonucleotides, such as poly-G, poly-C or poly-T (in vitro), but the physiological relevance of this is not certain. Does not bind poly-A. Enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA, expect ESR1-mediated transcription that is not only slightly increased, if at all