CNPY3

Chr 6p21.1

canopy FGF signaling regulator 3

Aliases:: CAG4A
MANE:: ENST00000372836.5

OMIM: 610774 ↗NCBI: 10695 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

CNPY3 · Q9BT09

v62025-08-01

Predicted Aligned Error matrix for CNPY3 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

72.6/ 100

Confident

278 residues

Confidence breakdown

Very high(≥ 90)30%
Confident(70–90)31%
Low(50–70)15%
Very low(< 50)24%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

DDG2P
BIALLELIC, autosomal or pseudoautosomal
Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

genetic developmental and epileptic encephalopathy
0.68
infantile spasms
0.37
hypertension, pregnancy-induced
0.23
neoplasm
0.10
breast carcinoma
0.07
breast cancer
0.07
cancer
0.07
smoking initiation
0.04
colon adenocarcinoma
0.04
central nervous system cancer
0.04

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Protein canopy homolog 3

Toll-like receptor (TLR)-specific co-chaperone for HSP90B1. Required for proper TLR folding, except that of TLR3, and hence controls TLR exit from the endoplasmic reticulum. Consequently, required for both innate and adaptive immune responses (By similarity)