CNTN2

Chr 1q32.1

contactin 2

Aliases:: TAG-1, TAX1
MANE:: ENST00000331830.7

OMIM: 190197 ↗NCBI: 6900 ↗Ensembl ↗

Annotations refreshed 1 month ago.

Predicted protein structure

AlphaFold predicted structure

CNTN2 · Q02246

v62025-08-01

Predicted Aligned Error matrix for CNTN2 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

85.7/ 100

Confident

1,040 residues

Confidence breakdown

Very high(≥ 90)57%
Confident(70–90)34%
Low(50–70)3%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Early onset or syndromic epilepsy
BIALLELIC, autosomal or pseudoautosomal

Disease associations (Open Targets)

benign adult familial myoclonic epilepsy
0.67
type 2 diabetes mellitus
0.46
diabetes mellitus
0.44
complex neurodevelopmental disorder
0.44
diabetic eye disease
0.41
Abnormality of the skeletal system
0.39
coronary artery disorder
0.39
epilepsy, familial adult myoclonic
0.38
coronary atherosclerosis
0.32
diabetic neuropathy
0.31

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Contactin-2

In conjunction with another transmembrane protein, CNTNAP2, contributes to the organization of axonal domains at nodes of Ranvier by maintaining voltage-gated potassium channels at the juxtaparanodal region. May be involved in cell adhesion