COA1

Chr 7p13

cytochrome c oxidase assembly factor 1

Aliases:: FLJ10803, MITRAC15
MANE:: ENST00000223336.11

OMIM: 614769 ↗NCBI: 55744 ↗Ensembl ↗

Annotations refreshed 9 hours ago.

Predicted protein structure

AlphaFold predicted structure

COA1 · Q9GZY4

v62025-08-01

Predicted Aligned Error matrix for COA1 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

88.2/ 100

Confident

146 residues

Confidence breakdown

Very high(≥ 90)72%
Confident(70–90)14%
Low(50–70)8%
Very low(< 50)6%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Moderate Evidence (Amber)

Mitochondrial disorder with complex IV deficiency
Unknown
Possible mitochondrial disorder - nuclear genes
Unknown
Likely inborn error of metabolism
Unknown
Mitochondrial disorders

Disease associations (Open Targets)

liver disorder
0.24
patellar tendinitis
0.22
neurodegenerative disease
0.19
colorectal carcinoma
0.07
neoplasm
0.05
cancer
0.05
colorectal cancer
0.02
giant cell tumor
0.01
metastatic malignant neoplasm in the lymph nodes
0.01
COVID-19
0.01

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Cytochrome c oxidase assembly factor 1 homolog

Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly. MITRAC complexes regulate both translation of mitochondrial encoded components and assembly of nuclear-encoded components imported in mitochondrion. Required for assembly of mitochondrial respiratory chain complex I and complex IV (PubMed:23260140). As part of the MCIA complex, required for efficient assembly of the mitochondrial complex I (PubMed:32320651)