COCH

Predicted protein structure

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

• Familial Meniere Disease

  MONOALLELIC, autosomal or pseudoautosomal, NOT imprinted

• Monogenic hearing loss

  BOTH monoallelic and biallelic, autosomal or pseudoautosomal

Disease associations (Open Targets)

• autosomal dominant nonsyndromic hearing loss

  0.71

• hearing loss, autosomal recessive 110

  0.69

• nonsyndromic genetic hearing loss

  0.51

• deafness

  0.49

• Rare genetic deafness

  0.46

• Non-syndromic genetic deafness

  0.39

• Hearing impairment

  0.36

• Sensorineural hearing impairment

  0.34

• neurodegenerative disease

  0.34

• Prelingual sensorineural hearing impairment

  0.33

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Diseases associated with COCH

Curated MONDO disease pages that list COCH among their top associated genes.

• autosomal dominant nonsyndromic hearing lossRare