COLEC10

Chr 8q24.12

collectin subfamily member 10

Aliases:: CL-L1, CL-10
MANE:: ENST00000332843.3

OMIM: 607620 ↗NCBI: 10584 ↗Ensembl ↗

Annotations refreshed 10 hours ago.

Predicted protein structure

AlphaFold predicted structure

COLEC10 · Q9Y6Z7

v62025-08-01

Predicted Aligned Error matrix for COLEC10 — diagonal shows residue index, colour shows pairwise prediction confidence (lower is better) — Predicted Aligned Error

Mean pLDDT

80.2/ 100

Confident

277 residues

Confidence breakdown

Very high(≥ 90)45%
Confident(70–90)24%
Low(50–70)25%
Very low(< 50)7%

Open interactive 3D viewer

AlphaFold (Jumper et al., 2021) · CC BY 4.0

Clinical relevance (Genomics England PanelApp)

Diagnostic Grade (Green)

Clefting
BIALLELIC, autosomal or pseudoautosomal
DDG2P
BIALLELIC, autosomal or pseudoautosomal
Fetal anomalies
BIALLELIC, autosomal or pseudoautosomal
Intellectual disability
Rare syndromic craniosynostosis or isolated multisuture synostosis
Skeletal dysplasia

Disease associations (Open Targets)

3MC syndrome
0.71
hypothyroidism
0.43
Microscopic hematuria
0.38
basal cell carcinoma
0.31
osteoporosis
0.31
keratinocyte carcinoma
0.29
bone disorder
0.29
infectious meningitis
0.28
nasal cavity polyp
0.15
hepatocellular carcinoma
0.12

Score is the Open Targets composite evidence score (0-1). Higher = stronger gene-disease association.

Protein function (UniProt)

Collectin-10

Lectin that binds to various sugars: galactose > mannose = fucose > N-acetylglucosamine > N-acetylgalactosamine (PubMed:10224141). Acts as a chemoattractant, probably involved in the regulation of cell migration (PubMed:28301481)